12 ETC
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- takes electrons from electron carriers
- 2 NADH outside have to be shuttled in via malate shuttle or glycerol phosphate shuttle
- mitochondria membrane convert glycerol phosphate back and generate FADH2, carry not as much energy. Some energy lost
Complex 1
Complex II
- CoQ deliver enzymes to complex 3
Complex III
- iron goes back and forth in cytochrome as opposed of Hgb
- phosphorylating ADP to make ATP via enzyme
- number of ATP generated per O2
Poisons
- uncoupling: ETC still working but not coupled to phosphorylation of ADP
- rotenone: inhibitor of reduction of CoQ
- CO binds Fe2 and competes with O2 for electron transfer
- cyanide no effect on RBC with Fe2
- progress to shock quickly
- O2 not extracted because ETC inhibited
- lactic acidosis: one of ways people die
- poke a hole in inner membrane
- DNP in research labs
- aspirin: fever, H+ leaking out generating heat
- normally lipolysis makes ATP
- brown fat: not coupled ETC, lipolysis generates heat
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